Published in
Cell Stem Cell, Cell Press (Reed Elsevier)
Content
Deng and colleagues developed stem cell-derived islets with controlled relative abundance of endocrine cell types, simultaneously possessing glucose-lowering and glucose-raising abilities. After reversal of hyperglycemia in diabetic mice recipients, these islets could sufficiently protect against hypoglycemia. They addressed a critical safety consideration in translating the therapeutic potential of SC-islets for diabetes.
Gaofan Meng, Jiabin Gu, Soon Yi Liew, Jingxiao Cao, Zhihui Wang, Chunyu Ma, Zhenzhen Fu, Hongwen Zhou, Jinlin Wang, Shusen Wang, Sijia Jing, Yiqi Wu, Zhengjun Lei, Shuli Zhi, Yuanyuan He, Cheng Li, Hongkui Deng
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