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Fibroblast bioelectric signaling drives hair growth

Journal content Created on 15 Aug 2025 by Cell

Published in

Cell, Cell Press (Reed Elsevier)

Content

Chen et al. reveal that bioelectric changes in dermal fibroblasts regulate hair growth. By activating the potassium channel KCNJ2, fibroblast hyperpolarization enhances regenerative Wnt signaling and promotes hair growth, offering a potential therapeutic strategy for treating hair loss through modulation of membrane potential.

Daoming Chen, Zhou Yu, Wenbo Wu, Yingxue Du, Qianqian Du, Huanwei Huang, Yaqi Li, Ting Xuan, Ya-Chen Liang, Yang Liu, Zijuan Wang, Rina Su, Yi Zhao, Qi Li, Minmin Luo, Fengchao Wang, Ji Li, Cheng-Ming Chuong, Zhimiao Lin, Ting Chen

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