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Rethinking RNA-binding proteins: Riboregulation challenges prevailing views

Journal content Created on 04 Sep 2025 by Cell

Published in

Cell, Cell Press (Reed Elsevier)

Content

The advent of system-wide proteomic approaches has largely expanded the number of RNA-binding proteins (RBPs). This review discusses how recent discoveries are transforming our understanding of biologically relevant RNA-protein interactions and highlights riboregulation as a widespread, underexplored mechanism through which RNA dynamically modulates protein function.

Matthias W. Hentze, Pia Sommerkamp, Venkatraman Ravi, Fátima Gebauer

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