Published in
Cell Stem Cell, Cell Press (Reed Elsevier)
Content
Compared with ground controls, ISS missions showed that spaceflight accelerates hallmarks of hematopoietic stem and progenitor cell (HSPC) aging, including decreased dormancy in AI-driven FUCCI2BL HSPC niche nanobioreactors, reduced replating capacity and ADAR1 self-renewal gene expression, impaired telomere maintenance, mitochondrial stress responses, APOBEC3C activation, and acquisition of clonal hematopoietic mutations.
Jessica Pham, Jane Isquith, Larisa Balaian, Shuvro P. Nandi, Claire Engstrom, Karla Mack, Inge van der Werf, Patrick Chang, Jana Stoudemire, Luisa Ladel, Emma Klacking, Antonio Ruiz, Daisy Chilin-Fuentes, Jenna Sneifer, David Mays, Paul Gamble, Shelby Giza, Jiya Janowitz, Trevor Nienaber, Tejaswini Mishra, Anna A. Khachatrian, Elsa Molina, Michael P. Snyder, Sheldon R. Morris, Twyman Clements, Alysson R. Muotri, Thomas Whisenant, Ludmil B. Alexandrov, Catriona H.M. Jamieson
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