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Modeling the human maternal-fetal interface

Journal content Created on 04 Sep 2025 by Cell Stem Cell

Published in

Cell Stem Cell, Cell Press (Reed Elsevier)

Content

This review explores the advances in stem cell and organoid models of the endometrium, placenta, and embryo, outlining challenges in integrating them to capture spatiotemporal dynamics and functional complexity of the maternal-fetal interface. The authors call for a shift from building individual models to building interactions, offering new insights into intrauterine human development.

Vladyslav Bondarenko, Margherita Yayoi Turco

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