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Severing the scar supply line: CAR-T in chronic kidney disease

Journal content Created on 04 Sep 2025 by Cell Stem Cell

Published in

Cell Stem Cell, Cell Press (Reed Elsevier)

Content

CAR-T cell therapy is rapidly being extended to target various pathophysiological processes beyond cancer. In this issue of Cell Stem Cell, Zhao et al. engineered PDGFRβ-specific CAR-T cells in vivo to selectively target extracellular matrix-producing cells in kidney fibrosis, opening new opportunities for treating fibrotic diseases with precision immunotherapy.

Longwei Liu, Yingxiao Wang

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