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Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states

Journal content Created on 06 Aug 2025 by Nature Genetics

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Nature Genetics, Nature Publishing Group

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Nature Genetics, Published online: 06 August 2025; doi:10.1038/s41588-025-02284-1

CRISPR activation of 1,836 human transcription factors recapitulates fibroblast transcriptional states observed in vivo and identifies regulators that can revert inflammatory states.

Thomas M. Norman

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