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PANCS-Binders: a rapid, high-throughput binder discovery platform

Journal content Created on 06 Aug 2025 by Nature Methods

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Nature Methods, Nature Publishing Group

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Nature Methods, Published online: 06 August 2025; doi:10.1038/s41592-025-02740-0

Phage-assisted noncontinuous selection of protein binders (PANCS-Binders) allows multiple high-diversity protein libraries to each be screened against a panel of dozens of targets for high-throughput protein binder discovery.

Bryan C. Dickinson

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