Noncatalytic telomerase function in inflammation

Journal content Created on 06 Aug 2025 by Nature Cell Biology

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Nature Cell Biology, Nature Publishing Group

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Nature Cell Biology, Published online: 06 August 2025; doi:10.1038/s41556-024-01497-6

Whether the telomerase protein TERT has moonlighting functions by acting catalytically in telomere elongation and non-catalytically in extratelomeric functions has long been debated. A study now demonstrates that TERT can regulate physiological levels of inflammatory signals independently of its catalytic functions.

Eric Gilson

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