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Peptide codes for organ-selective mRNA delivery

Journal content Created on 01 Sep 2025 by Nature Materials

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Nature Materials, Nature Publishing Group

Content

Nature Materials, Published online: 01 September 2025; doi:10.1038/s41563-025-02331-6

Tissue-specific mRNA or gene editing machinery delivery is achieved with lipid nanoparticles containing peptides with specific sequences, which tune the protein corona of the particles by mechanical optimization of peptide–protein binding affinities.

Yue Shao

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