Authors
Jiao Miao, Zu-Xin Yu, Chong-Yang Shi, Xin-Qi Zhu, Bo Zhou, Long-Wu Ye
Published in
The Journal of organic chemistry. Sep 04, 2025. Epub Sep 04, 2025.
Abstract
The generation of α-imino metal carbenes from readily available alkynes via nitrene transfer has emerged as an important advancement in carbene chemistry, but current methodologies remain constrained to noble-metal catalysts. Additionally, the dearomatization involving α-imino metal carbenes has not been unexplored. In this study, we disclose a copper-catalyzed dearomatization reaction of azides with ynamide-phenol derivatives via α-imino copper carbenes. This protocol enables the practical synthesis of various valuable 1H-pyrido[2,3-b]indoles in generally excellent yields with a broad substrate scope.
PMID:
40906940
Bibliographic data and abstract were imported from PubMed on 05 Sep 2025.
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