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Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice

Journal content Created on 11 Aug 2025 by Nature Neuroscience

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Nature Neuroscience, Nature Publishing Group

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Nature Neuroscience, Published online: 11 August 2025; doi:10.1038/s41593-025-02032-y

Activation of Gs signaling at mitochondria by mitoDREADD-Gs increases mitochondrial metabolism, leading to better memory in mouse models of dementia, directly linking brain mitochondrial deficits to cognitive symptoms of neurodegenerative diseases.

Etienne Hebert-Chatelain

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