Published in
Cell, Cell Press (Reed Elsevier)
Content
Loss of cellular identity across aging and disease is linked to a widespread “mesenchymal drift,” characterized by upregulation of mesenchymal genes and altered stromal cell composition across tissues. Mesenchymal drift correlates with worse clinical outcomes, whereas its suppression via Yamanaka factor-induced partial reprogramming restores youthful gene expression.
Jinlong Y. Lu, William B. Tu, Ronghui Li, Mingxi Weng, Bhargav D. Sanketi, Baolei Yuan, Pradeep Reddy, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte
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